Enter the area under the curve during single dose steady state and the area under the curve during a dose interval after one single dose into the Calculator. The calculator will evaluate the Accumulation Ratio. 

Accumulation Ratio Formula

Rac = AUCss / AUC1

Variables:

  • Rac is the Accumulation Ratio ()
  • AUCss is the area under the curve during single dose steady state
  • AUC1 is the area under the curve during a dose interval after one single dose

To calculate Accumulation Ratio, divide the area under the curve during single dose steady state by the area under the curve during a dose interval after one single dose.

How to Calculate Accumulation Ratio?

The following steps outline how to calculate the Accumulation Ratio.

  1. First, determine the area under the curve during single dose steady state. 
  2. Next, determine the area under the curve during a dose interval after one single dose. 
  3. Next, gather the formula from above = Rac = AUCss / AUC1.
  4. Finally, calculate the Accumulation Ratio.
  5. After inserting the variables and calculating the result, check your answer with the calculator above.

Example Problem : 

Use the following variables as an example problem to test your knowledge.

area under the curve during single dose steady state = 400

area under the curve during a dose interval after one single dose = 500