Enter the area under the curve during single dose steady state and the area under the curve during a dose interval after one single dose into the Calculator. The calculator will evaluate the Accumulation Ratio.

## Accumulation Ratio Formula

Rac = AUCss / AUC1

Variables:

- Rac is the Accumulation Ratio ()
- AUCss is the area under the curve during single dose steady state
- AUC1 is the area under the curve during a dose interval after one single dose

To calculate Accumulation Ratio, divide the area under the curve during single dose steady state by the area under the curve during a dose interval after one single dose.

## How to Calculate Accumulation Ratio?

The following steps outline how to calculate the Accumulation Ratio.

- First, determine the area under the curve during single dose steady state.
- Next, determine the area under the curve during a dose interval after one single dose.
- Next, gather the formula from above = Rac = AUCss / AUC1.
- Finally, calculate the Accumulation Ratio.
- After inserting the variables and calculating the result, check your answer with the calculator above.

**Example Problem : **

Use the following variables as an example problem to test your knowledge.

area under the curve during single dose steady state = 400

area under the curve during a dose interval after one single dose = 500