Enter the nonsynonymous nucleotide substitution rate and the synonymous nucleotide substitution rate into the Calculator. The calculator will evaluate the Ka/Ks Ratio.

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## Ka/Ks Ratio Formula

Ka:Ks = Ka/Ks

Variables:

- Ka:Ks is the Ka/Ks Ratio ()
- Ka is the nonsynonymous nucleotide substitution rate
- ks is the synonymous nucleotide substitution rate

To calculate Ka/Ks Ratio, divide the nonsynonymous nucleotide substitution rate by the synonymous nucleotide substitution rate.

## How to Calculate Ka/Ks Ratio?

The following steps outline how to calculate the Ka/Ks Ratio.

- First, determine the nonsynonymous nucleotide substitution rate.
- Next, determine the synonymous nucleotide substitution rate.
- Next, gather the formula from above = Ka:Ks = Ka/Ks.
- Finally, calculate the Ka/Ks Ratio.
- After inserting the variables and calculating the result, check your answer with the calculator above.

**Example Problem : **

Use the following variables as an example problem to test your knowledge.

nonsynonymous nucleotide substitution rate = 8

synonymous nucleotide substitution rate = 9