Enter the nonsynonymous nucleotide substitution rate and the synonymous nucleotide substitution rate into the Calculator. The calculator will evaluate the Ka/Ks Ratio.

Ka/Ks Ratio Formula

Ka:Ks = Ka/Ks

Variables:

• Ka:Ks is the Ka/Ks Ratio ()
• Ka is the nonsynonymous nucleotide substitution rate
• ks is the synonymous nucleotide substitution rate

To calculate Ka/Ks Ratio, divide the nonsynonymous nucleotide substitution rate by the synonymous nucleotide substitution rate.

How to Calculate Ka/Ks Ratio?

The following steps outline how to calculate the Ka/Ks Ratio.

1. First, determine the nonsynonymous nucleotide substitution rate.
2. Next, determine the synonymous nucleotide substitution rate.
3. Next, gather the formula from above = Ka:Ks = Ka/Ks.
4. Finally, calculate the Ka/Ks Ratio.
5. After inserting the variables and calculating the result, check your answer with the calculator above.

Example Problem :

Use the following variables as an example problem to test your knowledge.

nonsynonymous nucleotide substitution rate = 8

synonymous nucleotide substitution rate = 9