Enter the Gibbs free energy (J) and the number of non-hydrogen atoms into the calculator to determine the Ligand Efficiency.

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## Ligand Efficiency Formula

The following formula is used to calculate the Ligand Efficiency.

**EL = G / N **

- Where EL is the Ligand Efficiency
- G is the Gibbs free energy (J)
- N is the number of non-hydrogen atoms

## How to Calculate Ligand Efficiency?

The following two example problems outline how to calculate the Ligand Efficiency.

**Example Problem #1:**

- First, determine the Gibbs free energy (J). In this example, the Gibbs free energy (J) is given as 50.
- Next, determine the number of non-hydrogen atoms. For this problem, the number of non-hydrogen atoms is given as 144.
- Finally, calculate the Ligand Efficiency using the equation above:

EL = G / N

Inserting the values from above and solving the equation:

EL = 50 / 144 = .347

**Example Problem #2: **

Using the same process as above, first define the variables required by the formula. In this case, these values are:

Gibbs free energy (J) = 100

number of non-hydrogen atoms = 5055

Entering these values yields:

EL = 100 / 5055 = .0197