De-index eGFR to absolute mL/min using body surface area, estimate Cockcroft-Gault creatinine clearance, and compare both kidney function estimates.
References / Guidelines (for further reading)
- National Kidney Foundation (NKF): eGFR and kidney function overview pages.
- KDIGO: chronic kidney disease guideline overview materials.
- NIDDK or Mayo Clinic: patient education on eGFR/creatinine testing.
- Medication labeling (FDA/your countryโs regulator): renal dosing sections often specify whether to use CockcroftโGault CrCl vs eGFR.
- All Health and Medical Calculators
- All Medical and Health Unit Converters
- BSA Calculator โ Body Surface Area
- GFRC Weight Calculator
- Urine K To Creatinine Ratio Calculator
Indexed GFR To Absolute (Unindexed) GFR Formula
The following formula is used to convert a BSA-indexed GFR (mL/min/1.73mยฒ) into an absolute (unindexed) GFR (mL/min) using the patientโs body surface area (BSA). This conversion is not the same as a measured urine creatinine clearance.
Variables:
- GFRabsolute is the absolute (unindexed) GFR (mL/min)
- GFRindexed is the BSA-indexed GFR (mL/min/1.73mยฒ)
- BSA is the body surface area (mยฒ)
To calculate the absolute (unindexed) GFR, multiply the indexed GFR by the body surface area, then divide by 1.73 (the standard BSA used for indexing).
| GFR (mL/min/1.73mยฒ) | Absolute GFR at BSA 1.50 mยฒ (mL/min) | Absolute GFR at BSA 1.73 mยฒ (mL/min) | Absolute GFR at BSA 2.00 mยฒ (mL/min) |
|---|---|---|---|
| 15 | 13.0 | 15 | 17.3 |
| 20 | 17.3 | 20 | 23.1 |
| 25 | 21.7 | 25 | 28.9 |
| 30 | 26.0 | 30 | 34.7 |
| 35 | 30.3 | 35 | 40.5 |
| 40 | 34.7 | 40 | 46.2 |
| 45 | 39.0 | 45 | 52.0 |
| 50 | 43.4 | 50 | 57.8 |
| 55 | 47.7 | 55 | 63.6 |
| 60 | 52.0 | 60 | 69.4 |
| 65 | 56.4 | 65 | 75.1 |
| 70 | 60.7 | 70 | 80.9 |
| 75 | 65.0 | 75 | 86.7 |
| 80 | 69.4 | 80 | 92.5 |
| 85 | 73.7 | 85 | 98.3 |
| 90 | 78.0 | 90 | 104.0 |
| 95 | 82.4 | 95 | 109.8 |
| 100 | 86.7 | 100 | 115.6 |
| 110 | 95.4 | 110 | 127.2 |
| 120 | 104.0 | 120 | 138.7 |
| Formula: Absolute GFR (mL/min) = Indexed GFR (mL/min/1.73mยฒ) ร (BSA (mยฒ) / 1.73). Values rounded to one decimal place. | |||
What Is Indexed GFR vs. Creatinine Clearance?
GFR (glomerular filtration rate) describes how much fluid the kidneys filter per unit time. Many lab-reported eGFR values are indexed to a standard body surface area of 1.73 mยฒ (reported as mL/min/1.73mยฒ) so results can be compared across people of different sizes.
Creatinine clearance (CrCl) is different: it is typically measured from urine collection (e.g., 24-hour urine) or estimated from serum creatinine using formulas such as CockcroftโGault. CrCl and GFR are related but not interchangeable; CrCl often overestimates true GFR due to creatinine tubular secretion.
How to Convert Indexed GFR to Absolute (Unindexed) GFR
The following steps outline how to convert a BSA-indexed GFR to an absolute (unindexed) GFR.
- Determine the indexed GFR in mL/min/1.73mยฒ.
- Determine the patientโs BSA in mยฒ.
- Use the formula from above: Absolute GFR = (Indexed GFR ร BSA) / 1.73.
- Calculate the absolute (unindexed) GFR in mL/min.
- Check your answer with the calculator above.
Example Problem:
Use the following variables as an example problem to test your knowledge.
Indexed GFR = 80 mL/min/1.73mยฒ
BSA = 1.8 mยฒ
Absolute (unindexed) GFR = (80 ร 1.8) / 1.73 = 83.24 mL/min (โ 83.2 mL/min)
