Enter the progesterone and estradiol levels into the calculator to determine the Pg/E2 ratio. This ratio is sometimes used as one piece of information when discussing progesterone–estradiol balance.

Pg/E2 Ratio Calculator

Enter any 2 values to calculate the missing variable

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Pg/E2 Ratio Formula

The following formula is used to calculate the Pg/E2 ratio (unit-normalized so the result is unitless).

Pg/E2 Ratio = (Progesterone Level (ng/mL) × 1000) / Estradiol Level (pg/mL)

Variables:

  • Pg/E2 Ratio is a unitless value calculated as (progesterone in ng/mL × 1000) divided by estradiol in pg/mL.
  • Progesterone Level is the concentration of progesterone in the blood, commonly reported in nanograms per milliliter (ng/mL).
  • Estradiol Level is the concentration of estradiol in the blood, commonly reported in picograms per milliliter (pg/mL).

To calculate the Pg/E2 ratio, convert progesterone from ng/mL to pg/mL (multiply by 1000, since 1 ng = 1000 pg), then divide by the estradiol value in pg/mL.

What is a Pg/E2 Ratio?

The Pg/E2 ratio compares progesterone and estradiol, two key hormones in the body. It is sometimes referenced in discussions of reproductive health and hormone therapy, but interpretation depends on the clinical context, timing of the test (cycle phase), lab methods, and an individual’s symptoms.

How to Calculate Pg/E2 Ratio?

The following steps outline how to calculate the Pg/E2 Ratio.

  1. First, determine the progesterone level in the blood (ng/mL).
  2. Next, determine the estradiol level in the blood (pg/mL).
  3. Next, gather the formula from above = Pg/E2 Ratio = (Progesterone Level × 1000) / Estradiol Level.
  4. Finally, calculate the Pg/E2 Ratio.
  5. After inserting the variables and calculating the result, check your answer with the calculator above.

Example Problem : 

Use the following variables as an example problem to test your knowledge.

Progesterone Level (ng/mL) = 15 ng/mL

Estradiol Level (pg/mL) = 50 pg/mL

Pg/E2 Ratio = (15 × 1000) / 50 = 300