Enter the urine volume and osmolarity, along with any other osmolar losses, into the calculator to determine the total daily osmolar output.

Total Daily Osmolar Output Formula

The following formula is used to calculate the total daily osmolar output.

TDO = UV * UO + OL

Variables:

  • TDO is the total daily osmolar output (mOsm)
  • UV is the urine volume (liters)
  • UO is the urine osmolarity (mOsm/L)
  • OL is the other osmolar losses (mOsm)

To calculate the total daily osmolar output, multiply the urine volume by the urine osmolarity and add any other osmolar losses.

What is Total Daily Osmolar Output?

Total daily osmolar output is a measure of the total amount of solutes excreted in the urine and other losses over a 24-hour period. It is an important parameter in assessing kidney function and fluid balance in the body. This calculation can help healthcare providers understand a patient’s hydration status and guide treatment decisions, especially in critical care settings.

How to Calculate Total Daily Osmolar Output?

The following steps outline how to calculate the Total Daily Osmolar Output.


  1. First, determine the urine volume (UV) in liters.
  2. Next, determine the urine osmolarity (UO) in mOsm/L.
  3. Next, determine any other osmolar losses (OL) in mOsm.
  4. Next, gather the formula from above = TDO = UV * UO + OL.
  5. Finally, calculate the Total Daily Osmolar Output (TDO) in mOsm.
  6. After inserting the variables and calculating the result, check your answer with the calculator above.

Example Problem : 

Use the following variables as an example problem to test your knowledge.

urine volume (UV) = 2 liters

urine osmolarity (UO) = 600 mOsm/L

other osmolar losses (OL) = 200 mOsm