Enter the Insulin Sensitivity and an Insulin Response (or insulin secretion) measure into the calculator to determine the Disposition Index.

Disposition Index Calculator

Enter any 2 values to calculate the missing variable

Disposition Index Formula

The following formula is used to calculate the Disposition Index.

DI = IS \times IR

Variables:

  • DI is the Disposition Index (often reported as a unitless index when IS and IR are in compatible units)
  • IS is Insulin Sensitivity (e.g., SI from an IVGTT/minimal model, or another insulin sensitivity measure)
  • IR is an Insulin Response / insulin secretion measure (e.g., AIRg, the acute insulin response to glucose)

To calculate the Disposition Index, multiply the Insulin Sensitivity (IS) by the Insulin Response (IR) measure.

What is a Disposition Index?

A Disposition Index is a research metric used in diabetes and metabolic studies to describe β-cell function relative to insulin sensitivity. It is commonly calculated as insulin sensitivity multiplied by an insulin response (insulin secretion) measure. A lower Disposition Index generally indicates a higher risk of impaired glucose regulation and type 2 diabetes, because insulin secretion is not adequately compensating for reduced insulin sensitivity.

How to Calculate Disposition Index?

The following steps outline how to calculate the Disposition Index (DI) using the formula: DI = IS × IR.

  1. First, determine the value of Insulin Sensitivity (IS) using a validated method (for example, from an IVGTT/minimal model, euglycemic clamp, or another insulin sensitivity estimate).
  2. Next, determine the value of an Insulin Response (IR) / insulin secretion measure (for example, AIRg from an IVGTT).
  3. Ensure IS and IR units are compatible (so their product is interpreted consistently).
  4. Multiply IS by IR to obtain the Disposition Index: DI = IS × IR.
  5. After inserting the variables and calculating the result, check your answer with the calculator above.

Example Problem:

Use the following variables as an example problem to test your knowledge:

Insulin Sensitivity (IS) = 10

Insulin Response (IR) = 5

Disposition Index (DI) = ?

DI = IS × IR = 10 × 5 = 50