Enter the Serum Iron and Total Iron Binding Capacity into the calculator to determine the Iron Saturation. This calculator can also evaluate any of the variables given the others are known.

Iron Saturation Formula

The following formula is used to calculate the Iron Saturation.

IS = (SI / TIBC) * 100


  • IS is the Iron Saturation (%) SI is the Serum Iron (µg/dL) TIBC is the Total Iron Binding Capacity (µg/dL)

To calculate the Iron Saturation, divide the Serum Iron by the Total Iron Binding Capacity, then multiply the result by 100 to get the percentage.

What is a Iron Saturation?

Iron saturation, also known as transferrin saturation, is a medical test that measures the percentage of iron bound to transferrin, a protein that carries iron in the blood. This test is used to diagnose iron deficiency or iron overload disorders, such as anemia or hemochromatosis. A low iron saturation indicates iron deficiency, while a high iron saturation indicates iron overload.

How to Calculate Iron Saturation?

The following steps outline how to calculate the Iron Saturation using the formula: IS = (SI / TIBC) * 100.

  1. First, determine the Serum Iron (SI) value (µg/dL).
  2. Next, determine the Total Iron Binding Capacity (TIBC) value (µg/dL).
  3. Next, use the formula IS = (SI / TIBC) * 100 to calculate the Iron Saturation.
  4. Finally, calculate the Iron Saturation value (%).
  5. After inserting the variables and calculating the result, check your answer with the calculator above.

Example Problem:

Use the following variables as an example problem to test your knowledge.

Serum Iron (SI) value (µg/dL) = 50

Total Iron Binding Capacity (TIBC) value (µg/dL) = 200