Enter the area under the plasma concentration curve (mg ml-1 min) and the glomerular filtration rate (ml/min) into the Calculator. The calculator will evaluate the Dose Using the Calvert Equation. 

Dose Using the Calvert Equation Formula

D = AUC * (GFR + 25)

Variables:

  • D is the Dose Using the Calvert Equation (mg)
  • AUC is the area under the plasma concentration curve (mg ml-1 min)
  • GFR is the glomerular filtration rate (ml/min)

To calculate Dose Using the Calvert Equation, add the glomerular filtration rate to 25, then multiply this result by the area under the plasma concentration curve.

How to Calculate Dose Using the Calvert Equation?

The following steps outline how to calculate the Dose Using the Calvert Equation.

  1. First, determine the area under the plasma concentration curve (mg ml-1 min). 
  2. Next, determine the glomerular filtration rate (ml/min). 
  3. Next, gather the formula from above = D = AUC * (GFR + 25).
  4. Finally, calculate the Dose Using the Calvert Equation.
  5. After inserting the variables and calculating the result, check your answer with the calculator above.

Example Problem : 

Use the following variables as an example problem to test your knowledge.

area under the plasma concentration curve (mg ml-1 min) = 15

glomerular filtration rate (ml/min) = 2.3