Convert ng/mL or ng/L to pmol/L, or pmol/L back to ng/mL, by picking a hormone or protein preset or entering the substance’s molar mass.
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ng/mL to pmol/L Formula
The following formula is used to convert a concentration from nanograms per milliliter (ng/mL) to picomoles per liter (pmol/L).
Variables:
- pmol/L is the concentration in picomoles per liter
- ng/mL is the concentration in nanograms per milliliter
- MW is the molecular weight of the substance in grams per mole (g/mol)
To calculate pmol/L, multiply the ng/mL value by 106 and divide by the molecular weight of the selected analyte. Since each substance has a different molecular weight, the same ng/mL value can produce different pmol/L values.
What is ng/mL to pmol/L Conversion?
Converting ng/mL to pmol/L changes a mass-based concentration into a molar concentration. ng/mL tells you how much mass of a substance is present in a volume of liquid, while pmol/L tells you how many molecules of that substance are present in that same volume. This is especially useful in laboratory medicine, endocrinology, and biomarker analysis, where results may be reported in either conventional or SI units.
Because the conversion depends on molecular weight, different hormones and biomarkers require different conversion factors. For example, 1 ng/mL of testosterone converts to far more pmol/L than 1 ng/mL of insulin because testosterone has a much lower molecular weight.
How to Calculate ng/mL to pmol/L?
The following steps outline how to convert ng/mL to pmol/L.
- First, determine the concentration in ng/mL.
- Next, determine the molecular weight (MW) of the analyte in g/mol.
- Apply the formula: pmol/L = (ng/mL × 106) / MW.
- Interpret the result as the concentration in picomoles per liter.
- Use the calculator above to quickly convert values for common hormones and biomarkers.
ng/mL to pmol/L Conversion Table
The table below uses pmol/L = (ng/mL × 106) / MW and the rounded molar masses shown. Match the exact chemical form or protein construct; the prolactin row uses an illustrative monomer mass, not a universal value for every circulating prolactin form. Small differences from calculator presets can result from rounding.
| Analyte | Approx. MW (g/mol) | 1 ng/mL in pmol/L |
|---|---|---|
| Testosterone | 288.42 | 3467.17 pmol/L |
| Estradiol (E2) | 272.38 | 3671.34 pmol/L |
| Progesterone | 314.47 | 3179.95 pmol/L |
| Cortisol | 362.46 | 2758.93 pmol/L |
| Insulin (human) | 5808 | 172.18 pmol/L |
| 25-hydroxyvitamin D3 (calcifediol) | 400.65 | 2495.94 pmol/L |
| Prolactin (assumed monomer) | 22700 | 44.05 pmol/L |
Example Conversion
Use the following example to test your understanding of the conversion.
Value = 1 ng/mL
Analyte = Testosterone
Molecular Weight = 288.42 g/mol
pmol/L = (1 × 106) / 288.42 = 3467.17 pmol/L
Laboratories may report some hormones in ng/mL and others in pmol/L. Understanding this conversion helps compare values across reports, references, and international unit systems.
