Enter the initial and subsequent PSA levels and the time duration into the calculator to determine the PSA velocity.

Psa Velocity Formula

The following formula is used to calculate the PSA velocity.

PSA Velocity = (PSA2 - PSA1) / Time


  • PSA Velocity is the rate of change in PSA levels over time PSA1 is the initial PSA level PSA2 is the subsequent PSA level Time is the duration between the two PSA tests, usually in years

To calculate the PSA velocity, subtract the initial PSA level from the subsequent PSA level. Then divide the result by the time duration between the two PSA tests. The result is the PSA velocity, which indicates how quickly the PSA levels are changing.

What is a PSA Velocity?

PSA velocity is a term used in medicine to refer to the rate at which the level of prostate-specific antigen (PSA) increases in a man’s body over time. PSA is a protein produced by the prostate gland and its level can rise due to various conditions, including prostate cancer. Therefore, monitoring the PSA velocity can help doctors detect prostate cancer at an early stage and monitor the effectiveness of treatment.

How to Calculate Psa Velocity?

The following steps outline how to calculate the PSA Velocity:

  1. First, determine the initial PSA level (PSA1).
  2. Next, determine the subsequent PSA level (PSA2).
  3. Next, determine the duration between the two PSA tests (Time), usually in years.
  4. Next, subtract the initial PSA level (PSA1) from the subsequent PSA level (PSA2).
  5. Finally, divide the difference in PSA levels by the duration between the two tests to calculate the PSA Velocity.

Example Problem:

Use the following variables as an example problem to test your knowledge:

PSA1 (initial PSA level) = 5

PSA2 (subsequent PSA level) = 8

Time (duration between the two PSA tests) = 2 years