Enter the concentration of organic and aqueous partition into the calculator to determine the partition coefficient and LogP.

Log P Formula

The following formulas are used to calculate a partition coefficient and logP.

P = [O] / [A]

  • Where P is the partition coefficent
  • O is the concentration of organic partition
  • A is the concentration of aqueous partition

Log(P) = log10 (Partiion Coefficient)

Partition Coefficient Definition

What is a partition coefficient?

A partition coefficient describes the propensity of a compound (neutral) to dissolve in an immiscible biphasic system of lipids and water.

What is LogP?

LogP is a value that indicates whether a substance will be absorbed by plants, animals, humans, or other living tissue. In other words, how easily it can be carried away and disseminated by water.

Example Problem

How to calculate LogP?

  1. First, determine the concentration of the organic partition.

    For this example, the concentration of the organic portion is 65%. For this example, percentages are used for simplification of the calculation.

  2. Next, determine the concentration of the aqueous partition.

    In this case, the aqueous portion is 30%.

  3. Next, determine the partition coefficient.

    Divide the result from step 1 by the result in step 2 to get the partition coefficient.
    65/30 = 2.1666.

  4. Finally, calculate the LogP value.

    Log(P) = log10 (Partiion Coefficient)
    Log(P) = log10 (2.1666)
    Log(P) = .335