Enter the concentration of organic and aqueous partition into the calculator to determine the partition coefficient and LogP.

## Log P Formula

The following formulas are used to calculate a partition coefficient and logP.

P = [O] / [A]

• Where P is the partition coefficent
• O is the concentration of organic partition
• A is the concentration of aqueous partition

Log(P) = log10 (Partiion Coefficient)

## Partition Coefficient Definition

What is a partition coefficient?

A partition coefficient describes the propensity of a compound (neutral) to dissolve in an immiscible biphasic system of lipids and water.

What is LogP?

LogP is a value that indicates whether a substance will be absorbed by plants, animals, humans, or other living tissue. In other words, how easily it can be carried away and disseminated by water.

## Example Problem

How to calculate LogP?

1. First, determine the concentration of the organic partition.

For this example, the concentration of the organic portion is 65%. For this example, percentages are used for simplification of the calculation.

2. Next, determine the concentration of the aqueous partition.

In this case, the aqueous portion is 30%.

3. Next, determine the partition coefficient.

Divide the result from step 1 by the result in step 2 to get the partition coefficient.
65/30 = 2.1666.

4. Finally, calculate the LogP value.

Log(P) = log10 (Partiion Coefficient)
Log(P) = log10 (2.1666)
Log(P) = .335