Enter the standard deviation of the response of the curve and the slope of the calibration curve into the calculator to determine the limit of detection.
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Limit of Detection Formula
The following formula is used to calculate a limit of detection.
LOD = 3.3 * (Sy/S)
- Where LOD is the limit of detection
- Sy is the standard deviation of the response curve
- S is the standard deviation of the calibration curve
Limit of Detection Definition
A limit of detection is a term used in chemistry to describe the lowest concentration or quantity of a component that can be reliably detected with an analytical method.
Limit of Detection Example
How to calculate a limit of detection?
- First, determine the standard deviation of the response curve.
Calculate the standard deviation of the response curve of the data.
- Next, determine the standard deviation of the calibration curve.
Calculate the standard deviation of the calibration curve of the data.
- Finally, calculate the limit of detection.
Calculate the limit of detection using the equation above.
FAQ
A limit of detection, or LOD for short, is a measure of the lowest level of quantity that a certain analytical method can detect in any concentration of a component. This is most often used in chemistry.
