Enter the standard deviation of the response of the curve and the slope of the calibration curve into the calculator to determine the limit of detection.

- Relative Standard Deviation Calculator
- Percent Deviation Calculator
- Coefficient of Determination Calculator

## Limit of Detection Formula

The following formula is used to calculate a limit of detection.

LOD = 3.3 * (Sy/S)

- Where LOD is the limit of detection
- Sy is the standard deviation of the response curve
- S is the standard deviation of the calibration curve

## Limit of Detection Definition

A limit of detection is a term used in chemistry to describe the lowest concentration or quantity of a component that can be reliably detected with an analytical method.

## Limit of Detection Example

How to calculate a limit of detection?

**First, determine the standard deviation of the response curve.**Calculate the standard deviation of the response curve of the data.

**Next, determine the standard deviation of the calibration curve.**Calculate the standard deviation of the calibration curve of the data.

**Finally, calculate the limit of detection.**Calculate the limit of detection using the equation above.

## FAQ

**What is the limit of detection?**

A limit of detection, or LOD for short, is a measure of the lowest level of quantity that a certain analytical method can detect in any concentration of a component. This is most often used in chemistry.